Induction Therapy With Autologous Mesenchymal Stem Cells for Kidney Allografts

Inclusion Criteria: * Patients must be between the ages of 18 and 60 years and meet the institution's criteria for renal transplantation for end-stage renal failure * Patient is receiving the first renal transplant * Patient is receiving a renal transplant only * Women who are of child bearing potential must have a negative pregnancy test (urine test is acceptable) and agree to use reliable contraception for 1 year following transplant * Willing to comply with the study visits * Be able to sign informed consent document. Note: The subjects do not need to be local residents in order to be eligible for this trial, but must be willing to reside in the area, or within a four hour drive, for the first three months of the protocol so that we can monitor them closely in the early post transplant period. Exclusion Criteria: * Previously received or is receiving an organ transplant other than a kidney * Significant liver disease, defined as having continuously elevated AST (SGOT) or ALT (SGPT) levels greater than 3 times the upper value of the normal range within 28 days prior to study entry * HIV infection. * Surface antigen positive for HBV. * Antibody positive for hepatitis C virus * Recipient or donor is positive for tuberculosis (TB), under treatment for suspected TB, or previously exposed to TB * Currently receiving an investigational drug or received an investigational drug within 30 days prior to transplant. * Currently receiving any immunosuppressive agent. * Clinically active bacterial, fungal, viral or parasitic infection * Evidence for immunologic memory against donor. * Recipients need antibody induction treatment before the operation. * Current cancer or a history of cancer within the 5 years prior to study entry. * Serious heart and lung diseases. * Patients who's RPR is positive * Pregnancy or breastfeeding. * Have no ability to communicate. * Any form of substance abuse, psychiatric disorder, or other condition that, in opinion of the investigator, may interfere with the study