A Phase 1 Study of AIR645 in Healthy Subjects and Subjects With Controlled Asthma

Inclusion Criteria\*: * Good General Health (with or without allergic rhinitis and/or controlled asthma) * Non-smoker for at least 2 years * Normal lung function (DLCO) * Able to provide informed consent and to understand and comply with the requirements of the study Exclusion Criteria\*: * Clinically significant medical history or condition which precludes participation * Clinically significant ECG abnormality * Clinically significant VS or PE abnormality * Clinically significant screening lab abnormality * Abnormal lung function (FEV1 \<80% predicted) * Respiratory infection within 14 days of randomization * HBV, HCV, or HIV * Breastfeeding or pregnant female * History of alcohol abuse or illicit drug use within past 24 months * Use of any tobacco or nicotine-containing product within past 6 months * Use of any herbal supplement, over-the-counter drug, or prescription drug that is not allowed per protocol * Use of any investigational drug within past 30 days * Use of any investigational monoclonal antibody or recombinant protein within past 90 days * Donation of plasma within past 7 days * Donation or loss of whole blood within past 56 days * Simplified list of I/E criteria; unabridged list available upon request.