Treatment of Neuroleptic Induced Acute Akathisia With Trazodone

BeerYaakov Mental Health Center13 enrolled

Overview

Administration of trazodone for the treatment of neuroleptic induced acute akathisia in a cross-over fashion of 6 days duration. 3 days of placebo and 3 days of trazodone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Schizophrenia

Interventions

PlaceboDRUG

TrazodoneDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with akathisia according to DSM-IV criteria at least mild akathisia. Exclusion Criteria: * Change of pharmacologic regimen 7 days prior to study entry * Significant systemic disease * The presence of chronic akathisia * Patients unable to cooperate

Locations (1)

Beer Yaakov MHC

Beer Yaacov, Israel

Outcomes

Primary Outcomes

Barnes Akathisia rating scale, Positive and Negative syndrome scale, Hamilton Depression Rating Scale, Hamilton Anxiety Scale, Clinical Global Impression, Scale for the Assessment of Negative Symptoms

Data from ClinicalTrials.gov

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