Comparison of Acceleromyography (AMG) and Mechanomyography (MMG) for Establishing Potency of Neuromuscular Blocking Agents

Rigshospitalet, Denmark40 enrolled

Overview

The purpose of this study was to compare two methods for neuromuscular monitoring, acceleromyography and mechanomyography for establishing the dose-response relationship and the potency of a neuromuscular blocking agent using rocuronium as an example. We hypothesized that there would be no significant difference between potencies estimated using acceleromyography and mechanomyography.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Neuromuscular Blockade

Interventions

TOF-Watch SX (Acceleromyography)DEVICE

Randomization of AMG to dominant or non-dominant arm. MMG at contralateral arm.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-III * Ideal weight +/-20% * Both arms available for neuromuscular monitoring * Surgery in supine position * Participated surgery time more than 30 min Exclusion Criteria: * Pregnant and breast-feeding women * Patients with known illness or use of medications known to influence the neuromuscular transmission * Known significant renal or hepatic dysfunction * Allergy to medications used in the study

Locations (1)

Rigshospitalet

Copenhagen, Østerbro, Denmark

Outcomes

Primary Outcomes

Comparison of ED50 with the two methods

Secondary Outcomes

Comparison of ED95 with the two methods

Data from ClinicalTrials.gov

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