Endothelial Dysfunction Induced by Postprandial Lipemia

Norwegian University of Science and Technology8 enrolled

Overview

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood. Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy Subjects

Interventions

exercise trainingOTHER

moderate intensity exercise group, and high intensity exercise group

Eligibility

Sex: MALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male, 20-40years, BMI between 25 and 30, resident in Trondheim. Exclusion Criteria: * unstable angina, CHD, heart failure,

Locations (1)

NTNU

Trondheim, Norway

Outcomes

Primary Outcomes

Flow mediated dilatation

Time frame: baseline, post exercise, 30min, 2hour, 4hour post exercise

Secondary Outcomes

blood lipid profile

Time frame: same as flow mediated dilatation

Data from ClinicalTrials.gov

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