The Role of Central Serotonergic and Adrenergic Systems in the Effectiveness of DNIC (Diffuse Noxious Inhibitory Control

Rambam Health Care Campus64 enrolled

Overview

The role of central serotonergic and adrenergic systems in the effectiveness of DNIC (Diffuse Noxious Inhibitory Control) will be tested before and after taking Duloxetine and Placebo in a double blind study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Healthy

Interventions

DuloxetineDRUG

SNRIs

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * age 18-80 * no chronic disease Exclusion Criteria: * Subjects who suffer from chronic pain / pain syndrome * use of anti-depressant or anti-psychotic drugs * food/ drugs sensitivity * breast feeding

Locations (1)

Rambam Health Care Campus

Haifa, Israel

Outcomes

Primary Outcomes

level of DNIC

Time frame: 1 week

Data from ClinicalTrials.gov

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