Signal processing in the olfactory neuron could be influenced by inhibition of enzymes like phosphodiesterase. Pentoxifylline is a unspecific phosphodiesterase inhibitor. The hypothesis is that pentoxifylline could lead to increased sensitivity to odors.
Olfactory signal processing is conducted by a G-protein linked increase of intracellular concentration of adenosine 3´,5´-cyclic monophosphate (cAMP). In the cilia of olfactory sensory neurons (OSN) cAMP is degraded by phosphodiesterase 1C2 (PDE1C2). Inhibition of PDE1C2 could result in an increased response of OSN to chemical stimuli. Aim of the present prospective post-marketing surveillance study was to investigate the impact of pentoxifylline, an unspecific phosphodieasterase inhibitor, on olfactory function.
Study Type
OBSERVATIONAL
Enrollment
7
Agapurin retard 400mg 3/day per os for 3 weeks
Zentrum für Riechen und Schmecken, Universitäts- HNO- Klinik Dresden
Dresden, Germany
TDI-score
Time frame: at day 0 and follow up after 3 weeks
odor threshold odor discrimination odor identification
Time frame: at day 0 and at follow up after 3 weeks
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