Halt Growth of Liver Tumors From Uveal Melanoma With Closure of Liver Artery Following Injection of GM-CSF

Inclusion Criteria: * Metastatic uveal melanoma in the liver with histological confirmation * Ability/willingness to give informed consent * ECOG performance status of 0 or 1 * Adequate renal, liver and bone marrow function Exclusion Criteria: * Solitary liver metastasis that is amenable to surgical removal * Presence of symptomatic liver failure including ascites and hepatic encephalopathy * Presence of extra-hepatic metastases * Untreated brain metastases * Uncontrolled hypertension or congestive heart failure or acute myocardial infarction within 6 months of entry * Presence of any other medical complication that imply survival of less than six months * Uncontrolled sever bleeding tendency or active GI bleeding * Significant allergic reaction to contrast dye or GM-CSF * Immunosuppressive treatments such as systemic steroids, radiation to pelvis or systemic chemotherapy within 4 weeks * Previous embolization of the hepatic artery or intrahepatic arterial chemotherapy of liver metastasis * Active hepatitis with serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) greater than 5 x normal * HIV infection positive by ELISA * Pregnancy or breast feeding women * Biliary obstruction, biliary stent or prior biliary surgery except cholecystectomy * Significant arteriovenous shunt identified on angiography of the hepatic artery * Occlusion of main portal vein or inadequate collateral flow around an occluded portal vein