To Assess the Effect of Naproxcinod Versus Naproxen and Ibuprofen on Arterial Blood Pressure in Osteoarthritis Patients With Controlled Essential Hypertension

Inclusion Criteria: * Men/Women, 40 or older, diagnosed with hip or knee osteoarthritis. * Hypertensive Patient with treated and controlled essential hypertension. * Must receive at least one antihypertensive treatment from the following drug classes: Diuretic, Angiotensin-Converting Enzyme (ACE) inhibitor, Angiotensin Receptor Blockers (ARB) or Beta-Blocker (BB). * Must be current chronic user of NSAIDS or acetaminophen. * Must discontinue all analgesic therapy at Screening. Exclusion Criteria: * More than two different classes of antihypertensive drugs. * Uncontrolled diabetes. * Hepatic or renal impairment. * A history of alcohol/drug abuse. * Diagnosis of gastric or duodenal ulceration and/or history of significant gastro-duodenal bleeding. * History of congestive heart failure. * Clinically relevant abnormal ECG. * Current or history of a medical disease that could interfere with the study objectives or put the patient's safety at risk. * Current or expected use of anticoagulants. * Participation within 30 days prior to pre-screening in another investigational study.