Renal Denervation in Patients With Refractory Hypertension

Inclusion Criteria: * \>= 18 years of age * a systolic blood pressure of 160mmHg or more * receiving and adhering to full doses of at least three antihypertensive drugs * estimated glomerular filtration rate (eGFR) of ≥45mL/min * agrees to have the study procedure(s) performed and additional procedures and evaluations * is competent and willing to provide written, informed consent to participate in this clinical study Exclusion Criteria: * hemodynamically or anatomically significant renal artery stenosis * has a history or prior renal artery angioplasty * has experienced MI, unstable angina pectoris, or CVA within 6 months * has hemodynamically significant valvular heart disease * has Type 1 diabetes * has an implantable cardioverter defibrillator (ICD) or pacemaker, or any other metallic implant which is not compatible with magnetic resonance imaging (MRI) * requires respiratory support * is pregnant, nursing, or planning to be pregnant * has known, unresolved history of drug use or alcohol dependency. * is currently enrolled in another investigational drug or device trial.