Effect of Celecoxib on Transitional Pain After Outpatient Surgery

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Overview

Sixty adults having shoulder and forearm surgery will receive either placebo or celebrex started preoperatively and continued for 3 days. Rescue medications required as well as pain scores will be assessed using a patient diary to evaluate the effect of celebrex in controlling transitional pain

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Conditions

Pain

Interventions

celebrexDRUG

400 mg celebrex given 1 hour preop and celebrex 200 mg BID postop

placeboDRUG

placebo given preop and BID postop

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for elective ambulatory surgery of the shoulder * ASA I - III * Able to read English * Male or female Exclusion Criteria: * Allergy to local anesthetic, Cox2, sulpha drug, acetaminophen or oxycodone * Women who are pregnant or lactating and women of childbearing age and not following acceptable contraceptive precautions * Any major medical or psychiatric problem * Those with a known history of narcotic dependence, abuse or chronic narcotic intake * Patients with known history of peptic ulcer or GI bleeding in the past, ulcers, congestive heart failure, angina or previous heart attack, coagulation problems, venous thrombosis, kidney or liver disease or strokes

Locations (1)

St. Joseph's Health Care

London, Ontario, Canada

Outcomes

Primary Outcomes

visual analogue score for pain

Time frame: post-op period

Secondary Outcomes

severity of nausea

Time frame: post-op period

Data from ClinicalTrials.gov

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