Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity

Inclusion Criteria: * Age 18-45. Individuals over the age of 45 will not be included as we are examining the effects of menstrual cycle and ovarian hormones. * Daily smokers who smoke at least 10 cigarettes per day for at least past 6 months. * Post menarche and pre menopausal * Regular menstrual cycle between 25 and 35 days * At least three months post delivery and breast feeding * Desire to quit smoking and willingness to participate in a research study. * Women with a history of depression (but not current MDE) and current PMDD will be included. Excluding women with these diagnoses would have a major impact on feasibility, but because both disorders might impact treatment outcome, individuals will be stratified across randomization groups. Exclusion Criteria: * Any unstable major axis I psychiatric disorder in the past month * Current substance use disorders other than nicotine and caffeine use, in the past 30 days. * Any medication that may interfere with psychophysiological monitoring * Unstable medical or serious medical condition in the past 6 months * Hypersensitivity to varenicline or TNP * Use of other tobacco products * Use of other medications with smoking cessation efficacy within 30 days prior to enrollment * BMI less than 15 since this could alter hormone levels that affect menstrual phase * Pregnancy * Breast feeding * Status post hysterectomy * Birth control or HRT medication that would effect the menstrual cycle. Currently available oral contraceptives contain either a combination of a synthetic estrogen and synthetic progestin, or a progestin alone. Estrogen and/or progestin inhibit ovulation and alter cervical mucus and the endometrium by suppressing the production of follicle-stimulating hormone and the luteinizing hormone surge (Bucci \& Carson, 1997)