Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory pattern and effort in mechanically ventilated patients with rapid shallow breathing or high respiratory rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
14
0.05 mcg.kg-1.min-1 for 30 minutes by continuous endovenous infusion
NaCl 0.9 %
Intensive Care Unit, Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Italy
respiratory rate/tidal volume
Time frame: before and after remifentanil infusion; before and after placebo infusion.
pressure-time product
Time frame: before and after remifentanil infusion; before and after placebo infusion.
double product of respiratory system
Time frame: before and after remifentanil infusion; before and after placebo infusion.
dynamic intrinsic PEEP
Time frame: before and after remifentanil infusion; before and after placebo infusion.
adverse events
Time frame: during all the study period
arterial pH
Time frame: before and after remifentanil infusion; before and after placebo infusion.
level of sedation (RASS)
Time frame: before and after remifentanil infusion; before and after placebo infusion.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.