The Effect of the Combined Use of Naloxone and Tramacet on Postoperative Analgesia in the Elderly

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's10 enrolled

Overview

Ten patients 70 years and older having elective total hip/knee replacement surgery will be recruited to receive a continuous IV infusion of naloxone and oral tramacet for analgesia. Postoperative analgesia, satisfaction, side effects, need for rescure analgesia, and length of stay.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Arthroplasty

Interventions

tramacetDRUG

2 tablets every 6 hours for 5 days

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aged 70 years or older able to give consent able to communicate in English having elective hip/knee arthroplasty ASA physical status 1-3 Exclusion Criteria: * allergies to any of the following: naloxone, tramacet, NSAIDs, sulpha, or local anesthesic contraindication to spinal anesthesia contraindication to use of tramacet or celebrex ASA physical status4 chronic opiod use chronic pain syndrome

Locations (1)

St. Joseph's Health Care

London, Ontario, Canada

Outcomes

Primary Outcomes

opoid use post knee/hip arthroplasty

Time frame: post-op period

Secondary Outcomes

incidence of visual analogue scale scores greater than 4

Time frame: post-op period

Data from ClinicalTrials.gov

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