Platelet-Rich and Concentrated Platelet-Poor Plasma to Reduce Air Leak Post-Lobectomy: A Randomized Controlled Trial

Zimmer Biomet204 enrolled

Overview

The purpose of this study is to determine whether the use of platelet-rich plasma (PRP) and concentrated platelet-poor plasma (PPPc) can reduce the duration of post-operative air leak after lobectomy for lung tumours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

204

Conditions

Lung Cancer

Interventions

Standard post-lobectomy wound care plus use of PRP and PPPc prepared by GPS and Plasmax respectivelyPROCEDURE

GPS is used to create the platelet rich plasma (PRP). Plasmax is used to create the concentrated platelet-poor plasma (PPPc). Both PRP and PPPc will be used for wound care in the thoracic cavity post-lobectomy.

Standard post-lobectomy wound carePROCEDURE

Standard post-lobectomy wound care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients requiring a lobectomy Exclusion Criteria: * Pneumonectomy * Sleeve lobectomy * Determination of unresectability (prior to the initiation of lobectomy) * Wedge resection alone

Locations (1)

University of Western Ontario: Division of Thoracic Surgery

London, Ontario, Canada

Outcomes

Primary Outcomes

Duration of postoperative air leak

Time frame: Every 4 hours of postop hospital stay, between 4-6 weeks postop

Secondary Outcomes

Incidence of air leak, Prolonged air leak (> days), Complications

Time frame: Every 4 hours of postop hospital stay, between 4-6 weeks postop

Data from ClinicalTrials.gov

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