Bronchospasm Associated With High Nitric Oxide

University of Sao Paulo31 enrolled

Overview

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Asthma Airway Hyperresponsiveness

Eligibility

Sex: ALLMin age: 16 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with no systemic disease and registered bronchospasm during anesthesia induction Exclusion Criteria: * hypertension, COPD, diabetes, pregnancy

Locations (1)

Hospital das Clínicas da FMUSP

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Exhaled nitric oxide in parts per billion

Time frame: one to six months after surgery

Secondary Outcomes

Eosinophils concentration within sputum sample, pulmonary function tests

Time frame: one to six months after surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.