Research Tissue Bank

Icahn School of Medicine at Mount Sinai963 enrolled

Overview

This study that will allow for the preservation and/or storage of a small portion one or more of the following tissues: * Peripheral blood * Bone marrow * Bone marrow biopsy * A phlebotomized unit of blood * Spleen cells * Toenail clippings This material will be used for the study of Myeloproliferative Disorders (MPD) by researchers. The goals of this research study are to understand the causes of MPDs, how to diagnose them more easily and how to treat them better. MPD is a disease affecting hematopoietic stem cells. Hematopoietic stem cells are cells that make blood cells. These stem cells grow in the center portion of the bones called bone marrow. Under some conditions, these cells are also found in blood. There are several diseases, which are classified as MPD. These include polycythemia vera (too many red blood cells), essential thrombocythemia (too many platelets), and idiopathic myelofibrosis (abnormal blood cells and fibers build up in the bone marrow). These syndromes carry a high risk of developing leukemia. It is important to continue to learn more about these blood cancers and to learn more about the effectiveness and potential side effects of various treatments.

Study Type

OBSERVATIONAL

Enrollment

963

Conditions

Myelofibrosis Idiopathic Myelofibrosis Essential Thrombocythemia Polycythemia Vera

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with Philadelphia chromosome negative myeloproliferative disorders (MPD) polycythemia vera (PV), idiopathic myelofibrosis (IM), and essential thrombocythemia (ET) are eligible. * Newly diagnose MPD patients as well as previously treated for a MPD are eligible. * Signed informed consent is required from each patient at the time of enrollment. Exclusion Criteria: * Patients currently participating in experimental treatment arms of MPD-RC protocols, or other experimental treatment protocols are not eligible during the period they are on study.

Locations (11)

Palo Alto Medical Foundation Research Institute

Palo Alto, California, United States

Weill Cornell University

Washington D.C., District of Columbia, United States

University of Georgetown

Washington D.C., District of Columbia, United States

University of Illinois at Chicago

Chicago, Illinois, United States

Johns Hopkins

Baltimore, Maryland, United States

Roswell Park

Buffalo, New York, United States

Mount Sinai Medical Center

New York, New York, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

University of Utah

Salt Lake City, Utah, United States

Ospedali Riuniti di Bergamo

Bergamo, IL, Italy

...and 1 more locations

Outcomes

Primary Outcomes

To collect and store tissue specimens from patients with MPDs including PV, IM, ET. The samples will be used to conduct laboratory investigations to help define mechanisms involved in the pathophysiology and treatment of these disorders.

Time frame: 3 years