Microdialysis and Pharmacokinetic Study of TR-701

Inclusion Criteria: * Body mass index of 20 to 29 kg/m2 * Agree not to consume any products containing tobacco, alcohol, quinine, grapefruit, caffeine, or high levels of tyramine * Agree not to use any other medication * Female subjects must be postmenopausal (for at least 6 months), surgically sterile, abstinent, or, if sexually active, be practicing an effective method of birth control Exclusion Criteria: * History of gastric or duodenal ulcer within 1 year before enrollment * Has known or suspected hypersensitivity or intolerance to heparin, if an indwelling cannula (e.g., heparin lock) is used * Recent febrile illness (less than 72 hours before the first intake of study medication). * Significant blood loss (300 mL) or donation of blood within the 60 days before the Screening visit * Women who are pregnant or breast-feeding