Long-term Safety of Minocycline in Patients With Gum Disease

Inclusion Criteria: * generally healthy * over 25 years of age * moderate-to-severe chronic periodontitis * documented informed consent * willing to comply with contraceptive requirements * free from any significant oral soft tissue pathology Exclusion Criteria: * willing to adhere to prohibitions and restrictions of the study * oral health inappropriate for study inclusion * females self-reporting pregnancy or lactation, or having a positive urine pregnancy result * reporting any of the following conditions: * allergy to a tetracycline-class drug * systemic medical conditions requiring antibiotic prophylaxis prior to invasive dental procedures * active systemic infectious disease such as hepatitis, human immunodeficiency virus (HIV) or tuberculosis * diagnosed with clinically significant or unstable organic disease, or compromised healing potential, heart murmurs, histories of rheumatic fever, valvular disease or prosthetic joint replacement * participation in a dental clinical trial or use of an investigational drug within 30 days of enrollment * employees of the Investigator or study center, with direct involvement in the proposed study or other studies, as well as family members of the employees or the Investigator * anyone who the investigator determines should not be included in the study for any reason that could compromise safety or the analysis of study results