Chondroitin Sulphate Efficay/Safety in Patients With Knee Osteoarthritis and Psoriasis

Inclusion Criteria: * Primary knee OA according to ACR criteria; * OA of radiological stages 1 to 3 according to Kellgren-Lawrence; * VAS of pain ≥30; * PASI ≥ 5. Exclusion Criteria: * Known allergy to chondroitin sulphate; * Other bone and articular diseases such as chondrocalcinosis, Paget's disease, rheumatoid arthritis, psoriatic arthritis, acromegaly, hemochromatosis, Wilson's disease; * Patients with skin conditions that could interfere in the clinical trial evaluation