BAYQ3939, 1000 mg Tablet in Transrectal Needle Biopsies of the Prostate (TRNBP) - Infection Prophylaxis

Inclusion Criteria: * Transrectal needle biopsy of the prostate required. * A clean-catch midstream-urine (MSU) culture negative (\<104 CFU/mL) for possible pathogens at the Pre-Therapy Visit prior to the TRNBP. * Gastrointestinal absorption is adequate as evidenced by passage of gas or feces per rectum and patient can tolerate oral food, fluids, and medication without vomiting or diarrhea. Exclusion Criteria: * History of hypersensitivity to ciprofloxacin or other quinolone antibiotics * Valvular heart disease that requires antibiotic prophylaxis to prevent bacterial endocarditis * Concomitant use of theophylline, probenecid, or warfarin at any time during the entire study * Renal insufficiency * Known or suspected central nervous system disorder that may predispose to seizures or lower the seizure threshold * Absolute neutrophil count (ANC) \<1000/mm3 * Human immunodeficiency virus (HIV) infection with a CD4 count \<200 cells/micL. HIV testing is NOT required * Antibiotic administration within one week of the TRNBP * Severe hepatic insufficiency (Child-Pugh C)