This randomized study will examine the efficacy, safety and acceptability of misoprostol for treatment of incomplete abortion. Women diagnosed with incomplete abortion will be randomized to receive one of the following regimens: In Tanzania and Mozambique: 1. 600 mcg of oral misoprostol in one dose, or 2. Standard surgical treatment (MVA) In Moldova and Madagascar: 1. 600 mcg of oral misoprostol in one dose, or 2. 400 mcg of sublingual misoprostol in one dose. In Burkina Faso and Vietnam: 1\. 400 mcg of sublingual misoprostol in one dose. We hypothesize that treatment of incomplete abortion with either 400 mcg sublingual misoprostol, 600 mcg oral misoprostol or MVA are equally effective in evacuating the uterus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
720
comparison of orally administered 600mcg of misoprostol to either sublingually administered 400mcg or Manual Vacuum Aspiration (MVA)
comparison of orally administered 600mcg of misoprostol to either sublingually administered 400mcg or Manual Vacuum Aspiration (MVA)
Hôpital de District Sanitaire Dandé
Bobo-Dioulasso, Burkina Faso
Hôpital de District Sanitaire de Ziniaré
Ouagadougou, Burkina Faso
Befelatanana Maternity Centre
Antananarivo, Madagascar
Municipal Clinical Hospital
Chishinau, Moldova
Jose Macamo Hospital
Maputo, Mozambique
Kagera Regional Hospital
Bukoba, Tanzania
complete resolution of signs/symptoms of incomplete abortion without recourse to surgery at any point for any reason
Time frame: one week after initial treatment with the option of an additional week
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