Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake

Gunma University

Overview

Purpose: L-\[3-18F\]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer (NSCLC). Method: Thirty-seven NSCLC patients were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. Uptake of PET tracers was evaluated with standardized uptake value. VEGF, CD31, CD34, LAT1 and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers.

Study Type

OBSERVATIONAL

Conditions

Angiogenesis Non-Small Cell Lung Cancer

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study * Histology is non-small cell lung cancer Exclusion Criteria: * Patient who received neoadjuvant chemotherapy or radiotherapy before surgery * Patients who have insulin-dependent diabetes

Locations (1)

Gunma University Graduate School of Medicine

Showa-machi, Maebashi, Gunma, Japan

Data from ClinicalTrials.gov

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