Efficacy of Ramelteon on Transient Insomnia in Healthy Adults

Inclusion Criteria * Females of childbearing potential who are sexually active must agree to use adequate contraception, and can neither be pregnant nor lactating from Screening throughout the duration of the study. * Habitual bedtime is between 8:30 p.m. and 12:00 a.m. * Sleeps 6.5 to 8 hours per night and has a subjective sleep latency of less than or equal to 30 minutes. * Body mass index between 18 and 34, inclusive. Exclusion Criteria: * Any history of insomnia. * Spent one or more nights in a sleep laboratory. * Epworth Sleepiness Scale score of greater than 10. * Known hypersensitivity to Ramelteon or related compounds, including melatonin. * Previously participated in a study involving Ramelteon. * Participated in any other investigational study and/or taken any investigational drug within 30 days or five half-lives prior to Day 1, whichever is longer. * Sleep schedule changes required by employment (ie, shift work) within three months preceding Day 1 or has flown across greater than three time zones within seven days prior to screening. * Participated in a weight loss program or substantially altered their exercise routine within 30 days prior to Day 1. * History of seizures, sleep apnea, chronic obstructive pulmonary disease, restless leg syndrome, schizophrenia, bipolar disorder, mental retardation, or cognitive disorder. * History of a psychiatric disorder (including anxiety or depression) within the past 12 months. * History of drug addiction or drug abuse within the past 12 months. * Any physical or psychiatric disorder that may be associated with sleep disturbance. * History of alcohol abuse within the past 12 months, as defined in Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Revised and/or regularly consumes 4 or more alcoholic drinks per day. * Current significant neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary, hematologic or metabolic disease. * Uses tobacco products during nightly awakenings. * Any clinically important abnormal finding as determined by a medical history, physical examination, electrocardiogram, or clinical laboratory tests, as determined by the investigator. * Positive hepatitis panel. * Positive urine drug screen including alcohol at screening or a positive breathalyzer test at check-in. * Any additional condition(s) that in the investigator's opinion would * affect sleep-wake function * prohibit the subject from completing the study * not be in the best interest of the subject. * Is required to take or continues taking any disallowed medication, prescription medication, herbal treatment or over-the counter medication, including: * Anxiolytics * Hypnotics * Antidepressants * Anticonvulsants * Sedating H1 antihistamines * Systemic steroids * Respiratory stimulants (eg, theophylline) * Decongestants * Over-the-counter and prescription stimulants * Over-the-counter and prescription diet aids * Central nervous system active drugs * Narcotic analgesics * All beta blockers * St. John's Wort * Kava-kava * gingko biloba