The primary aim of the study is to assess whether 6-months of vitamin D supplements can decrease PTH compared with placebo treatment in primary hyperparathyroidism.
The study investigates effects and safety of six months of vitamin D supplementation before and after surgery in primary hyperparathyroidism. Effects are assessed as changes in calcium homeostasis, bone metabolism, quality of life, and muscle strength and function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
46
2800 IE daily in 52 weeks
Osteoporoseklinikken, Aarhus University Hospital, THG
Aarhus C, Denmark
Decrease in Preoperative P-PTH
Decrease in plasma PTH after 25 weeks of preoperative vitamin D treatment compared with the plasebo Group.
Time frame: 25 weeks
Improved Muscular Function
Time frame: One Year
Reduced Postoperative Hypocalcemia
Time frame: Postoperative week
Increase in Quality of Life
Time frame: One year
Increased Bone Mineral Density
Time frame: One year
Increase in Trabecular and Cortical vBMD Measured by QCT and pQCT of Hip, Spine and Forearm
Time frame: one year
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