Children with congenital hyperinsulinism (CHI) have low blood sugar, and some of these children may require surgery. In this study, researchers affiliated with the University of Pennsylvania will test how well a radioactive drug (called F-DOPA) can detect a form of hyperinsulinism that may be cured by surgery. Eligible participants in this study will have positron emission tomography (PET) scans with F-DOPA prior to surgery.
For children with congenital hyperinsulinism (CHI), low blood sugar is caused by cells in the pancreas that release too much insulin. Some children with CHI have these cells throughout their pancreas; others have them located in specific areas of the pancreas. Children who have them located in specific areas of the pancreas may be cured with surgery. F-DOPA is a radioactive drug that may go to these very cells. F-DOPA can also be used for positron emission tomography (or PET), an imaging technique used in nuclear medicine departments. In this study, researchers will test the possibility of using PET with F-DOPA in the diagnosis of children with hyperinsulinism.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
106
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
The Accuracy of FDOPA PET to Identify Focal Forms of Hyperinsulinism
Comparison of PET scan results with outcome of surgery and histopathology results confirmed as focal or diffuse
Time frame: up to 1 month post surgical intervention
Safety of F-DOPA PET
Number of Participants with Adverse Events
Time frame: 72 hours maximum or prior to pancreatic surgery
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