A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function

Inclusion Criteria: * Male or female aged 18 to 75 years with stable mild to moderate renal insufficiency. * Male or female aged 18 to 75 years with similar distribution of age, weight, gender, smoking habits, and race, and in general good health Exclusion Criteria: * Any significant acute or chronic disease (except renal impairment) which may interfere with study evaluations. * A history of alcohol or drug abuse. * Diagnosis of gastric or duodenal ulceration and/or history of significant gastro-duodenal bleeding within the last 6 months * Clinically relevant abnormal ECG * Current or expected use of anticoagulants or analgesic, anti-inflammatory therapies except low dose aspirin (less than or equal to 325mg per day). * Participation within 30 days prior to screening in another investigational study.