This study aims to determine the effectiveness of antenatal corticosteroid therapy in late preterm babies. The investigators hypothesis is corticoid accelerates fetal lung maturation even after 34 weeks and reduces risk of respiratory distress syndrome and other neonatal morbidities.
Late preterm babies have important morbidity when compared with term babies, with oxygen requirement and more days of hospitalization. If antenatal corticosteroid therapy is necessary for fetal lung maturation after 34 weeks, it remains to be established. The systematic review with metanalysis in Cochrane Library includes a small number of late preterm babies and no conclusion about effectiveness of corticoid therapy in this setting could be drawn. Our hypothesis is that antenatal corticosteroid therapy is effective to prevent respiratory disease and morbidity in late preterm babies and this study will be carried out to evaluate this question.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
320
IM administration of 12mg of betamethasone each 24 hours (total dose=24mg)
Instituto Materno Infantil Prof. Fernando Figueira
Recife, Pernambuco, Brazil
neonatal respiratory distress
Time frame: neonatal period (28 days of life)
during of neonatal hospitalization
Time frame: neonatal period (28 days of life)
neonatal oxygen requirement
Time frame: neonatal period (28 days of life)
neonatal sepsis
Time frame: neonatal period (28 days of life)
neonatal death
Time frame: neonatal period (28 days of life)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.