Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure. However,norepinephrine may have negative influence on several organs causing reduced blood flow ischemia. Our hypothesis is that hydrocortisone treatment may reduce the amount of vasoactive drugs needed to keep the blood pressure stable in patients selected for organ donation.
When patients are treated in the ICU only as possible organ donators they will be assessed for eligibility for the study. Iv hydrocortisone or placebo will be administered every 6 hours. Several hormonal samples will be collected.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
38
hydrocortisone 50mg iv. every 6 hours
sodium chloride every 6 hours iv
Kuopio University Hospital
Kuopio, Finland
Tampere University Hospital
Tampere, Finland
dosage and time on norepinephrine treatment
Time frame: in ICU
Hormone levels and number of organs donated
Time frame: Hospital treatment
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