Physical Exercise Versus Rosiglitazone in CAD and Prediabetes

University of Leipzig45 enrolled

Overview

The aim of this study is to prospectively assess the relative benefits of either treatment with rosiglitazone or physical exercise on endothelial function in patients with impaired fasting glucose or impaired glucose tolerance and coronary artery disease (CAD).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Impaired Glucose Tolerance

Interventions

rosiglitazoneDRUG

tablets 4 mg daily

physical exerciseBEHAVIORAL

stationary bike 5-6 times a week

controlOTHER

control without intervention

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * impaired fasting glucose or impaired glucose tolerance * angiographic evidence of coronary artery disease Exclusion Criteria: * diabetes mellitus type I or II * preexisting antidiabetic medication * unstable angina * indication for coronary bypass surgery * significant left main disease * myocardial infarction within preceding 3 months * ejection fraction \< 40% * significant heart valve disease * severe metabolic disorders * severe disorders in lipoprotein metabolism * thyroid disorders * alcohol or drug abuse * pregnancy * participation in another trial

Outcomes

Primary Outcomes

between-group difference in flow-mediated dilation of the brachial artery

Time frame: 6 months

Secondary Outcomes

relative effects of treatment on parameters of - glucose metabolism - inflammatory plasma markers - markers of endothelial function - cellular markers in muscle and fat biopsies

Time frame: 6 months

Data from ClinicalTrials.gov

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