Comparison of Skin Substitutes Used in Burn Care

The University of Texas Medical Branch, Galveston158 enrolled

Overview

The purpose of this study is to determine if using a DERMAL LAYER under skin grafts: 1. will reduce scar formation of skin grafts 2. will reduce burn wound contractures 3. will improve functional outcome of joints requiring grafts Compare scarring outcome of Dermal products

Various skin substitutes are compared for healing, scar and functional and cosmetic outcomes.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

158

Conditions

Burns

Interventions

IntegraPROCEDURE

Grafting using the Commercial product Integra as a skin substitute over full thickness burn following excision.

AlloDermPROCEDURE

Grafting using the commercial product AlloDerm as a skin substitute

HomograftPROCEDURE

Grafting using homograft as a skin substitute

Eligibility

Sex: ALLMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Burn injury requiring grafting * 0 years-90 years Exclusion Criteria: * Partial thickness burns only

Locations (2)

University of Texas Medical Branch, Galveston

Galveston, Texas, United States

University of Texas Medical Branch

Galveston, Texas, United States

Outcomes

Primary Outcomes

Burn Scar Comparison

Burn scar is measured scar using the Vancouver Scar Scale (range 0-12) for each of the various skin substitutes used in grafting. Vancouver Scar Scale measure burn scarring assessing categories of redness/vascularity, hardness, pigmentation and scar height. Each item has a scale of 0-3. Score for each category is summed together for a total score between 0-12. The total score is generally used in the burn community, therefore the total score will be reported. Lower scores are better; higher scores are worse.

Time frame: 2 years post burn injury

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.