Biological Investigations in Active Surveillance (BIAS) IGAR 2008 I 19 in Prostate Cancer Using High Field MRI (3 Tesla), PET, and Biomarkers

Inclusion Criteria: * Histologically proven adenocarcinoma of the prostate * Registration must occur within 16 weeks of last biopsy * History and physical exam (including DRE) within 8 weeks prior to registration * Patients must have indolent prostate cancer including all of the following: Low risk prostate cancer, less or equal to 50 % of core biopsies involved with disease, and less or equal to three biopsies involved with disease * Patients must have a minimum of six biopsies (sextant) at registration * PSA test within 8 weeks registration * Creatinine level below 100 umol/L within 8 weeks of registration * Patients must have no contraindications to MRI scans * No history of previous malignancies except non-melanoma skin tumors or other malignancies with a greater than 5 year life expectancy * Patients must be reliable for follow up Exclusion Criteria: * Patient does not have histologically-proven adenocarcinoma of the prostate * Last biopsy greater than 16 weeks prior to registration * History and physical exam (including DRE) greater that 8 weeks prior to registration * Patient does not have indolent disease * Patient has less than six sextant biopsies at registration * PSA test done greater than 8 weeks from registration * Creatinine level greater than 100 umol/L within 8 weeks of registration * Contraindications to MRI scans * History of previous malignancies other than non-melanoma skin tumors or other malignancies with a greater than 5 year life expectancy * Patients that are not reliable for follow up