Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest

Beth Israel Deaconess Medical Center50 enrolled

Overview

The major goal of this project is to determine whether the use of physiologic doses of corticosteroids will decrease time to shock reversal, alters the inflammatory cascade, and alters microcirculatory flow in post-cardiac arrest patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Cardiac Arrest

Interventions

Normal SalineDRUG

Normal Saline

HydrocortisoneDRUG

Hydrocortisone 100mg

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Greater than 18 years old * Either pre-hospital cardiac arrest and ROSC or Inpatient Cardiac Arrest with resultant ROSC * Vasopressor dependent for a minimum of 1 hour post-arrest Exclusion Criteria: * Pregnant * Indication for Corticosteroids outside of current research proposal * DNR or comfort care measures * Presence of septic shock * Chronic Use (\>1week) of oral Corticosteroids in the last year

Locations (1)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Time to Shock Reversal

The primary outcome was time to shock reversal defined as at least 24 hours off all vasopressor medications.

Time frame: 7 Days

Secondary Outcomes

Mortality

Time frame: Length of hospital stay, an average of 9 days with a maximum of 36 days

Sub-group Analysis of Patients With Adrenal Insufficiency

Sub-analysis of patients with adrenal insufficiency: absolute insufficiency as defined by a baseline cortisol level \< 15 ug/dL

Time frame: At time of enrollment

Data from ClinicalTrials.gov

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