This study will analyse the dose-dependent effect of olmesartan medoxomil on the change in arterial stiffness in subjects with hypertension and metabolic syndrome
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
133
dosage form: oral tablet; frequency: daily; duration: 52 weeks
dosage form: tablet; frequency: daily; duration: 3 weeks
dosage form: oral tablet; frequency: daily; duration: 52 weeks
Unnamed facility
Ghent, Belgium
Unnamed facility
Nuremberg, Germany
Unnamed facility
Monza, Italy
The change from baseline in carotid-femoral pulse wave velocity (PWV)
Time frame: Up to 1 year of double-blind treatment
The change from baseline in carotid-femoral PWV, after adjustment for change from baseline in mean blood pressure (MBP)as measured at the same visit
Time frame: Up to 1 year of double-blind treatment
On blood pressure (BP) lowering, assessed by conventional BP measurement and 24h ambulatory BP measurement (24h-ABPM)
Time frame: Up to 1 year of double-blind treatment
On central pulse pressure (PP) and augmentation index (AI)
Time frame: Up to 1 year of double-blind treatment
On common carotid stiffness, intima-media thickness (IMT), and internal diameter
Time frame: Up to 1 year of double-blind treatment
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dosage form: oral tablet; frequency: daily; duration: 52 weeks