The Effect of Autologous Autovaccine in Patients With Allergy on House-dust-mite

Johann Wolfgang Goethe University Hospital8 enrolled

Overview

House dust mite allergy is a common problem, resulting in asthma, chronic swelling of the eyes, and running nose. The investigators test a possibility to immunize subjects sensitized against house dust mite with extracts from their own gut bacteria "auto-vaccination".

see above

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Allergens, House Dust Mites

Interventions

Injection of autovaccine (Autovaccine Symbiopharm)BIOLOGICAL

increasing dosage schedule, six different concentrations, application over six weeks, 2 weeks break, another six weeks, 2 weeks break, than challenge with inhalative house dust mite extract

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * informed consent * age 18-35 years * known allergy on house-dust mite * GINA 0-1 Exclusion Criteria: * anamnestic incompatibility to parts of autovaccine * asthma \> GINA I° * chronic disease conditions or infections * pregnancy * inhalative or systemic steroid use * any immunosuppressive therapy * intake of any other probiotic medication (e.g. E.coli nissle 1917) * participation in any other study at the same time * substance abuse * Incapability of understanding the study's purpose and performance * smoker

Locations (1)

Goethe University, Department of Pulmonology

Frankfurt am Main, Hesse, Germany

Outcomes

Primary Outcomes

Patients' clinical parameters and behaviour, laboratory values

Time frame: jul 2006 - august 2008

laboratory testing reflecting function of bone marrow, liver, kidney

Time frame: jul 2006- august 2008

Secondary Outcomes

Lung function,exhalative NO

Time frame: jul 2006 - oct 2007

Data from ClinicalTrials.gov

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