Sex Differences in Gene Expression in Human Adipose Tissue

University of California, San Diego10 enrolled

Overview

This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand: 1. The mechanisms of differential body fat distribution in men and women 2. How body fat distribution is affected by reproductive hormones 3. The mechanisms linking fat distribution to health risks such as diabetes

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy Obesity

Interventions

Adipose BiopsyPROCEDURE

Adipose tissue will be sampled from the abdomen and buttock

Blood samplePROCEDURE

Blood will be sampled from an IV line

CT ScanRADIATION

Single image at the level of the liver

Eligibility

Sex: ALLMin age: 20 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Caucasian men and women 20-35 years of age * Lean (BMI less than 25) * Obese (BMI 30-35) Exclusion Criteria: * Hormonal birth control * Pregnancy * Smokers * History of diabetes, kidney, liver or thyroid disease * History of cancer

Locations (1)

UCSD

La Jolla, California, United States

Outcomes

Primary Outcomes

Adipose and blood sampling

Time frame: 1 year

Secondary Outcomes

CT scan and DEXA scan

Time frame: 1 year

Data from ClinicalTrials.gov

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