The Effect of Atorvastatin on Renal Function in Healthy Subjects During Normal and High Sodium Intake

Regional Hospital Holstebro23 enrolled

Overview

We wanted to test the hypothesis that acute treatment with atorvastatin changes renal sodium handling, renal hemodynamics, tubular function and vasoactive hormones in healthy humans during normal and high sodium intake. We wanted to analyze if changes in renal hemodynamics, tubular function, hormones, blood pressure and HR under acute treatment with atorvastatin depends on sodium intake.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Healthy Subjects

Interventions

AtorvastatinDRUG

80 mg atorvastatin on two following days each

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 20-50 yr 2. BMI\<30 3. Females had to use oral contraceptive treatment or IUD. Exclusion Criteria: 1. Clinical signs or history of disease of the heart, lungs, kidneys, liver, brain or endocrine organs 2. Abnormal laboratory blood tests (hemoglobin, sodium, potassium, albumin, creatinine, blood glucose, bilirubin, alanin amino transferase, alkalic phosphatase) 3. Albuminuria or glucosuria 4. cancer 5. arterial hypertension 6. alcohol abuse 7. medical treatment, except contraceptives 8. pregnancy or breast feeding 9. blood donation one month before the study.

Locations (2)

Department of Medical Research, Holstebro Hospital

Holstebro, Denmark

Medical Research

Holstebro, Denmark

Outcomes

Primary Outcomes

Glomerular filtration rate, clearance of sodium and lithium, fractional excretion of sodium and lithium, U-AQP-2, total sodium excretion, free water clearance

Time frame: 6 months

Secondary Outcomes

AVP, Ang-II, Aldosterone, ANP, BNP, PRC, BP and HR.

Time frame: 6 months

Data from ClinicalTrials.gov

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