This study will compare olmesartan medoxomil to candesartan cilexetil in reducing BNP, a prognostic biomarker of heart failure, at week 24
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
400
Dosage form: tablet; frequency: daily; duration: 24 weeks
Dosage form: tablets; frequency: daily; duration: 24 weeks
Unnamed facility
Bron, France
Unnamed facility
Cedex, France
Unnamed facility
Cholet, France
Unnamed facility
Langres, France
Absolute BNP change from week 0 to 24 of treatment
Time frame: 24 weeks
Proportion of BNP responders at week 4, 8, 16 and 24 (BNP levels reduced to 350 pg/ml or less at all time points)
Time frame: 24 weeks maximum
BNP change from week 0 to week 4, 8, and 16
Time frame: 16 weeks maximum
Incidence of critical events at 24 weeks: All cause death; Cardiovascular death defined as death due to: HF, myocardial infarction, cardiac arrhythmia, stroke/cerebral vascular accident, other cardiovascular cause (e.g., aneurysm or pulmonary embolism)
Time frame: 24 weeks
Event-free survival
Time frame: 24 weeks
Time-to-death
Time frame: 24 weeks
Time-to-first cardiovascular event
Time frame: 24 weeks maximum
Change in clinical status: Improvement: patient alive without any cardiovascular event with an improvement of at least one NYHA functional class level; No change: patient alive without any cardiovascular event with stable functional NYHA class
Time frame: 24 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Unnamed facility
Mannheim, France
Unnamed facility
Pontoise, France
Unnamed facility
Roubaix, France
Unnamed facility
Bad Nauheim, Germany
Unnamed facility
Berlin, Germany
Unnamed facility
Lambrecht, Germany
...and 1 more locations