Pregnancy/Implantation Rates Using a Day 3 Score Versus Graduated Embryo Score Plus a Biochemical Marker (sHLA-G)

University of Stellenbosch214 enrolled

Overview

Objective: To compare pregnancy rates and implantation rates when embryos are selected based on a single Day 3 (D.3) score vs. a GES score plus sHLA-G expression.

Comparing pregnancy rates and implantation rates when embryos are selected using the most common criteria for embryo selection on day 3 - the morphology-(number of blastomere, their shape and size and the percentage of fragmentation)vs a graduated embryo score accumulated over 72 hours and the expression of sHLA-G at 44-46 hours post fertilization.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

214

Conditions

Infertility

Interventions

Human derived FSHDRUG

Customized for each patient

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Self paying ART patients Exclusion Criteria: * Abnormal uterus * Specific Immunologic factors

Outcomes

Primary Outcomes

Pregnancy and implantation rates

Time frame: 12 weeks

Secondary Outcomes

Miscarriage rates

Time frame: 9 months

Miscarriage rates

Time frame: 9-11 day until βhCG

Data from ClinicalTrials.gov

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