Hemodynamic Measurements During Liver Transplantation

Washington University School of Medicine30 enrolled

Overview

The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.

Pulmonary artery catheter (PAC)is considered the gold standard in monitoring of heart function during orthotopic liver transplantation (OLT). Placement of PAC is very invasive (it passes thorough the heart chambers and into the pulmonary artery) and its benefits on the outcomes have not been proven. This study compares two newer FDA approved much less invasive devices to the PAC. The two new devices assess the heart function based either on the peripheral arterial waveform alone (Vigileo, Edwards Lifesciences)or the combination of peripheral arterial waveform and chemical indicator dilution (LiDCO, Cambridge, UK).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Transplantation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients over 18 years of age * Scheduled for liver transplantation * Patient undergoing vascular surgery where invasive arterial pressure is indicated (control subjects) Exclusion Criteria: * We will exclude patients taking lithium based medication * Patients who weigh less than 40 kg; AND * Patients who are pregnant

Locations (1)

Washington University School of Medicine

St Louis, Missouri, United States

Outcomes

Primary Outcomes

Agreement between cardiac output measurements obtained with PAC, Vigileo and LiDCO

Time frame: Specific phases of liver transplantation surgery

Data from ClinicalTrials.gov

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