The aim of this study is to evaluate the significance of an elevated high-risk HPV (HR-HPV) viral load.
We will particularly evaluate if the HR-HPV viral load: * Is correlated to the transcription of the genes of the oncoproteins E6 and E7 * Is predictive of the integration of the virus in infected cells * Is predictive of the presence of HPV in patients' blood * Influences the local and systemic immunologic response
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
149
* 2 cervical takings * 2 sampling of blood before and after the total hysterectomy
* cervical taking during the cervical conization * 2 sampling of blood before and after the intervention
* cervical taking during the pelvien examination under general anesthetic realized systematically during the balance sheet of pre-therapeutic evaluation * 2 sampling of blood before and after the intervention
Hopital Nord, service de gynécologie-obstétrique
Marseille, France
Estimate the meaning of a viral load raised in HPV oncogenic
Time frame: 36 months
To estimate the correlation enters the vorale load of the HPV oncogenic and the severity of the cervical hurt
Time frame: 36 months
Estimate the correlation between the viral load of the HPV oncogenic and the level of transcription of the genes coding for oncoproteines E6 and E7
Time frame: 36 months
Estimate the correlation between the viral load in HPV oncogenic and the integration of the viral genome in that of the infected cells
Time frame: 36 months
Estimate the correlation between a viral load raised in HPV oncogenic and a presence of HPV in the circulating blood of the infected patients
Time frame: 36 months
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