Efficacy and Safety Study of 4975 in Patients Undergoing Total Hip Replacement

Key Inclusion Criteria: * Male or female aged 18 to 85 years with an American Society of Anesthesiologists (ASA) status of I, II, III * Planning to undergo unilateral THA * In good health and capable of undergoing THA with spinal block and sedation anesthesia * No additional planned surgeries during the course of the trial * Willing and able to complete the study procedures and pain scales and to communicate meaningfully in English Key Exclusion Criteria: * A body mass index greater than 40 * Known bleeding disorder or is taking agents affecting coagulation preoperatively * A medical condition that could adversely impact the patient's participation, safety, or conduct of the study * Diabetes mellitus with a known HbA1C\>9.5 or a history of prolonged uncontrolled diabetes * Previous hip arthroplasty of the same hip * Participated in another clinical trial within 30 days of the planned hip surgery