Insulin and Polycystic Ovary Syndrome

Inclusion Criteria: * Obese women with PCOS and normal women aged 18-40, * PCOS less than 8 periods/year, elevated total or free testosterone, normal thyroid function tests and serum prolactin, exclusion of adrenal hyperplasia * Normal regular monthly periods, no clinical evidence of androgen excess, * All Acceptable health on interview, medical history, physical exams and lab tests, signed, witnessed informed consent and ability to comply to study requirements Exclusion Criteria: * DM, clinically significant pulmonary, cardiac, renal, hepatic, neurologic, psychiatric, infectious, neoplastic or malignant disease.