Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment

Assistance Publique Hopitaux De Marseille60 enrolled

Overview

The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change

The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Alzheimer's Disease

Interventions

Neurological and neuropsychological consultation, MRIOTHER

Neurological and neuropsychological consultation, MRI for the month 0, 18 and 36

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNAOTHER

Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA, months 0/18/36

Eligibility

Sex: ALLMin age: 50 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients beforehand include in the PHRC 2001 study (These patients presented to the inclusion in the PHRC 2001 a qualified board of amnestic Mild Cognitive Impairment \[aMCI\] or light cognitive confusion of type amnestic) * The patient must be affiliated to an insurance scheme disease to participate in this study Exclusion Criteria: * For the magnetic resonance imaging: usual contraindications for an examination by MRI: claustrophobia, metal foreign bodies, pacemakers, etc. * Incapacitated to realize the neuropsychological evaluation because of medical intercurrentes disorders * Appointment of a guardian

Locations (1)

Hopital de la Timone- Service de neurologie et de neuropsychologie

Marseille, France

Outcomes

Primary Outcomes

Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis

Time frame: 36 months

Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement.

Time frame: 36 months

Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation

Time frame: 36 months

Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement.

Time frame: 36 months

Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old.

Time frame: 36 months

Secondary Outcomes

Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY.

Time frame: 36 months

Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible.

Time frame: 36 months

Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease.

Time frame: 36 months

Data from ClinicalTrials.gov

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