Phase I of Human Papillomavirus (HPV) DNA Plasmid (VGX-3100) + Electroporation for CIN 2 or 3

Inclusion Criteria: * Written informed consent in accordance with institutional guidelines; * Female 18-45 years of age; * Post surgical (including LEEP and conization) or ablative treatment and a diagnosis of CIN 2 or 3, while under physician care as per ASCCP guidelines (Appendix D); * Normal ECG and normal laboratory values as judged by Grade 0-1 as per Toxicity Grading Scale for Healthy Adults (Appendix C) for CBC, CPK, SMA-12 and urinalysis evaluations done up to 30 days prior to administration of study treatment; * Body mass index (BMI) ≤30 kg/m2; * Women of child-bearing potential (WOCBP) agree to remain sexually abstinent, use medically effective contraception (oral contraception, barrier methods, spermicide, etc), or have a partner who is sterile (i.e., vasectomy) from enrollment to 3 months after the last injection (\~6 months); * Able and willing to comply with all study procedures. Exclusion Criteria: * Active infection with herpes simplex virus (HSV); * Positive serological test for HIV virus, hepatitis C virus or Hepatitis B virus surface antigen (HBsAg); * Pregnant or breastfeeding subjects; * Any concurrent condition requiring the continued use of systemic or topical steroids (excluding inhaled and eye drop-containing corticosteroids) or the use of immunosuppressive agents. All other corticosteroids must be discontinued \> 4 weeks prior to Day 1 of treatment;; * Administration of any blood product within 3 months of enrollment; * Administration of any vaccine within 6 weeks of enrollment; * Patient is currently participating or has participated in a study with an investigational compound or device within 30 days of signing informed consent; * Metal implants at the site of injection; * Active drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements; * Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (i.e. infections disease) illness must not be enrolled into this study; * Any other conditions judged by the investigator that would limit the evaluation of a subject.