The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia

Inclusion Criteria: * Who had the treatment of BPH with alpha-1 blockers for more than 3 months * Who have the IPSS(International Prostatic Symptom Score) \>= 15 * Who have the maximum flow rate(Qmax) \< 15 with voided volume \> 150mL * Who have the PPBC(patient's perception of bladder condition) \>= 3 (The PPBC was assessed by the use of a six point ordered categorical scale(1-6 point). The higher score means the higher bother) * Who had the PSA level \< 4 ng/mL within 6 months (But, the patient who are revealed not to have prostate cancer by prostate biopsy can be included even if he had PSA level of 4-10 ng/mL) * Who underwent the transrectal ultrasound of prostate within 6 months * Who can understand this study and can give the informed consent Exclusion Criteria: * Who had regular intake of 5-alpha reductase inhibitor or NSAID within 6 months before screening * Who have peptic ulcer and/or asthma * Who have urologic malignancies such as prostate cancer and bladder cancer * Who have urethral strictures, large bladder diverticuli, and bladder neck contractures * Who had surgical treatment for BPH * Who have histories of bladder and/or urethra * Who have serum PSA level more than 10 ng/ml * Who have histories of orthostatic hypotension * Who have serum creatinine level more than 2.0 mg/dl * Who have serum ALT and/or AST level more than 1.5 times of normal upper limit * Who have heart failure * Who have histories of bacterial prostatitis within 1 year * Who have histories of active urinary tract infection within 1 month * Who have histories of the biopsy of bladder and prostate within 1 month * Who are unable to void * Who use pads because of incontinences * Who have hypersensitivities for alpha blockers that include quinazoline, NSAID, aspirin, sulfonamide * Who have histories of unstable angina, myocardial infarction, and cerebrovascular accident within 6 months * Who have neurogenic bladder due to multiple sclerosis, Parkinson's disease, Spinal injuries and etc. * Who have thinking disturbances * Who have histories of abuses of alcohol and/or other drugs * Who seem to be not fit to this study by the decision of investigators