Effect of the Fixed Dose Combination Amlodipine/Valsartan on Central Aortic Blood Pressure in Uncontrolled Essential Hypertension With Amlodipine 5 mg

Novartis Pharmaceuticals393 enrolled

Overview

Assess that for an equivalent brachial blood pressure (BP)lowering, a fixed dose combination amlodipine/valsartan based regimen reduces central aortic BP pressure to a larger extent than an atenolol/amlodipine combination based regimen.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

393

Conditions

Hypertension

Interventions

Valsartan/amlodipine 80/5 mg tabletsDRUG

Amlodipine 5 mg capsulesDRUG

Amlodipine 10 mg capsulesDRUG

Atenolol 50 mg tabletsDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female patients 18 years of age or older * Hypertension defined by MSDBP \> 90 and or MSSBP \> 140 mmHg, MSDBP \> 80 mmHg, or/and MSSBP \> 130 mmHg if diabetes or chronic renal impairment uncontrolled under their previous therapy, or untreated , or experiencing unacceptable side effects * Written informed consent to participate in the study prior to any study procedures Exclusion Criteria: * Severe hypertension (grade 3 WHO classification MSDBP \> 110 mmHg and/or MSSBP \> 180 mmHg) * Evidence of a secondary form of hypertension * Type 1 diabetes mellitus * History of congestive heart failure, unstable coronary insufficiency, life threatening arrhythmia, significant valvular disease, second or third degree heart block etc.

Locations (1)

2 & 4 rue Lionel Terray BP 308

Rueil-Malmaison, France