Study to Compare Different Formulations of AZD3355

AstraZeneca48 enrolled

Overview

The purpose of the study is to compare different formulations of AZD3355 in regard to possible adverse events such as sensations of numbness, tinglings and heat in the skin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Gastroesophageal Reflux Disease

Interventions

AZD3355DRUG

Single dose

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Provision of written informed consent * Female subjects with no childbearing potentials or using highly efficient contraceptive methods * Clinically normal physical findings Exclusion Criteria: * Clinically significant illness within 2 weeks prior to the first dose of investigational product * History of clinically significant disease * Use of prescribed medication during the 2 weeks before administration of the first dose of investigational product

Locations (1)

Research Site

Varvsgatan, Lulea, Sweden

Outcomes

Primary Outcomes

Specific AE questions

Time frame: During 0-4 hours post dose

Secondary Outcomes

PK variables

Time frame: Frequent sampling up to 36 hours post dose

Safety variables (other adverse events, blood pressure, pulse, safety lab)

Time frame: During the whole treatment period

Data from ClinicalTrials.gov

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