Antibiotics in Patients With Acute Respiratory Tract Infection With Procalcitonin as Parameter

Hannover Medical School571 enrolled

Overview

Antibiotics in patients with acute respiratory tract infections in primary care in consideration of procalcitonin as additive parameter. The purpose of this study is to compare the ordinary manner of antibiotic- prescription with the prescription in consideration of procalcitonin-value in patients with acute respiratory tract infections.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

571

Conditions

Respiratory Tract Infection

Interventions

laboratory value procalcitoninOTHER

A. attending physician includes patient with acute respiratory infection in study, indicates antibiotic prescription and collects procalcitonin-value. Waits for decision from laboratory either "change of decision" or "retention of decision". In case of "change decision": antibiotic is not recommended, patient shall not take antibiotic. In case of "retention of decision": patient may take the antibiotic. B. attending physician includes patient with acute respiratory infection in study, indicates NO antibiotic and collects procalcitonin-value. Waits for decision from laboratory either "change of decision" or "retention of decision". In case of "change decision": antibiotic is recommended, patient has to be informed about. In case of "retention of decision": no change.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * Informed consent * Respiratory tract infection based on the clinical judgement of the primary care physician Exclusion Criteria: * Antibiotic pretreatment in previous 14 days * Portal hypertension * Major surgeries or multiple trauma which require hospitalization, in previous 4 weeks * Autoimmune disease and systemic diseases (lupus erythematodes, wegener´s disease) * Peritoneal dialysis * Acute treated or recently operated medullary c-cell-carcinoma, SCLC, carcinoid * Other inflammatory diseases (e.g. urinary tract infection, pyelonephritis, pancreatitis

Locations (1)

Medical School Hannover, Department Pneumology

Hanover, Germany

Outcomes

Primary Outcomes

days with significant impairment due to acute respiratory tract infection

Time frame: 14 to 28 days after infection

Secondary Outcomes

number of antibiotic prescriptions

Time frame: 28 days

Data from ClinicalTrials.gov

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