The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater improvement in employment status and overall psychosocial functioning than patients who receive standard care.
Preliminary results from a pilot study demonstrated that cognitive behavioural therapy (CBT) is associated with a significant benefit for patients with dissociative seizures. The current study aims to extend these findings by conducting a randomised controlled trial comparing CBT with standard outpatient medical care. Standard outpatient care has been chosen as the comparison treatment as it most closely resembles what is currently offered to this group of patients by the National Health Service. The primary outcome measure will be seizure frequency. Secondary outcome measures will be work and social adjustment and health service use. Our hypothesis is that CBT will be superior to standard outpatient care for patients with dissociative seizures as determined by the above measures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
70
CBT, up to 12 sessions.
Routine review by neuropsychiatrist in outpatient clinic
Maudsley Hospital
London, United Kingdom
seizure frequency
Time frame: previous month
seizure freedom
Time frame: 3 months
Work & Social Adjustment scale (Marks, 1986)
Time frame: Pre-treatment, end of treatment and six-months follow-up
Employment Status
Time frame: Pre-treatment, end of treatment and six-months follow-up
Health Service Use
Time frame: Pre-treatment, end of treatment and six-months follow-up
Hospital Anxiety and Depression Scale (Zigmond & Snaith, 1983)
Time frame: Pre-treatment, end of treatment and six-months follow-up
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